September 26-27, 2023
Polycystic kidney diseases (PKD) comprise a group of renal cystic disorders that are accompanied by a broad array of extrarenal manifestations. These disorders are a major cause of morbidity in adults and children. Autosomal dominant PKD is the most common single gene disorder that results in end-stage kidney disease. Autosomal recessive PKD is rare but more severe, resulting in perinatal mortality in 30-40 percent of affected infants. Although the most common causative genes for PKD (PKD1, PKD2, and PKHD1) were identified more than 2 decades ago, we still lack effective therapies, and major questions remain in our understanding of disease pathogenesis. The PKD RRC seeks to address these gaps by creating a collaborative framework that develops and shares research resources to support innovation in PKD research.
The PKD RRC is composed of a central coordinating site (University of Maryland, Baltimore); three research and translation core centers (The University of Alabama at Birmingham; Kansas University Medical Center; University of Maryland, Baltimore); and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
- Identify state-of-the-art techniques that could be applied to advance our understanding of PKD biology.
- Discuss challenges and gaps in PKD research that, if addressed, could move the field forward.
- Promote broad awareness of advances in PKD research and highlight existing PKD research resources.
- Foster interaction among members of the scientific community, including PKD researchers, early-stage investigators, and researchers who are new to the PKD field.
- Obtain feedback from the research community, with respect to what tools and resources are necessary to advance PKD research.
C.J. Haycraft – Chair (The University of Alabama at Birmingham); Patricia Outeda Garcia – Co-Chair, Terry Watnick, Nicole M. Reed, Victoria Halperin-Kuhns, Feng Qian, (University of Maryland School of Medicine); Whitney Besse (Yale School of Medicine); Amanda Clark, Taka Saigusa (The University of Alabama at Birmingham); Anubhav Chakraborty, Robin Maser, Pam Tran (The University of Kansas Medical Center); Christine Maric-Bilkan (National Institutes of Health - NIDDK).
September 20, 2023