Time: November 17, 2020 to January 19, 2021

Objectives: The workshop is organized by the Office of Research Infrastructure Program (ORIP) in collaboration with the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Aging (NIA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute of General Medical Sciences (NIGMS), and the National Institute of Neurological Disorders and Stroke (NINDS), and will be held as a series of sessions. This workshop will provide a venue to discuss the status and needs regarding the validation of animal models used in biomedical research. The focus of this workshop series will be on identifying obstacles, technology and resource gaps, and new approaches for assessing the value and limitations of animal models used to address basic science questions and/or to study human diseases.

Agenda

 
Session I. Validation of Invertebrate Models for Preclinical Research
Time/Date: 2-4 p.m. ET on November 17, 2020
Chairs: Hugo Bellen, Baylor College of Medicine
Julie Simpson, University of California Santa Barbara
 
2:00-2:05 p.m. Opening Remarks
Sige Zou, Program Official, ORIP, NIH
Franziska Grieder, Director, ORIP, NIH
Stephanie Murphy, Division Director, ORIP, NIH
 
2:05-3:30 p.m. Presentations:
Julie Simpson, University of California Santa Barbara
Goals of the invertebrate workshop

Erik Jorgensen, University of Utah
High-throughput gene tagging in C. elegans

Gerald Rubin, Howard Hughes Medical Institute
Stock Centers and high-resolution light and EM imaging tools

Benjamin White, National Institute of Mental Health
The potential benefits of GPCR biosensors, scarless split inteins, and methods for manipulating dense-core vesicle release

Meng Wang, Baylor College of Medicine
Metabolic imaging and profiling in model organisms

Norbert Perrimon, Harvard Medical School
Protein tagging, Nanobodies, proximity labeling methods and user friendly bioinformatic tools for data mining

Greg Jefferis, MRC Laboratory of Molecular Biology
An integrated molecular and connectomics atlas of brain cell types in Drosophila
 
3:30-4:00 p.m. Group Discussion
 
Session II. Validation of Zebrafish Models for Preclinical Research
Time/Date: 2-4 p.m. ET on November 24, 2020
Chairs: William Talbot, Stanford University
Rebecca Burdine, Princeton University
 
2:00-2:05 p.m. Opening Remarks
Sige Zou, Program Official, ORIP, NIH
Franziska Grieder, Director, ORIP, NIH
Stephanie Murphy, Division Director, ORIP, NIH
 
2:05-3:30 p.m. Presentations:
William Talbot, Stanford University
Zebrafish models of neurological disease

Gerald Downes, University of Massachusetts Amherst
Zebrafish Models of Genetic Epilepsies: Challenges and Opportunities

Monte Westerfield, University of Oregon
Zebrafish models validate undiagnosed human diseases

Lilianna Solnica-Krezel, Washington University
Forward and reverse genetic approaches in zebrafish to understanding scoliosis

Leonard Zon, Boston Children's Hospital
Cellular Barcoding in Zebrafish Models of Disease

Lalita Ramakrishnan, University of Cambridge
Zebrafish as models for infectious diseases

Rebecca Burdine, Princeton University
A New Era for Rare Disorders
 
3:30-4:00 p.m. Group Discussion
 
Session III. Validation of Mouse Models for Preclinical Research (to be updated)
Time/Date: 2-4 p.m. ET on December 1, 2020
Chairs: Catherine Lutz, The Jackson Laboratory
Douglas Wallace, Children's Hospital of Philadelphia
 
2:00-2:05 p.m. Opening Remarks
Sige Zou, Program Official, ORIP, NIH
Franziska Grieder, Director, ORIP, NIH
Stephanie Murphy, Division Director, ORIP, NIH
 
2:05-3:30 p.m. Presentations:
Craig Franklin, University of Missouri
Gut Microbiota: Variability and Translatability in Rodent Models

Catherine Kaczorowski, The Jackson Laboratory
Reproducible animal models for complex human disease: implications for personalized medicine

Leonard Shultz, The Jackson Laboratory
Next Generation Humanized Mice in Biomedical Research

Kenneth Chien, Karolinska Institutet, Sweden
Humanized mouse models for cardiovascular regenerative therapeutics

Leonard Guarente, MIT
Development of a Drug Discovery Platform for Dysferlinopathy-Based Muscular Dystrophies
 
3:30-4:00 p.m. Group Discussion
 
Session IV. Validation of Large Animal Models for Preclinical Research
Time/Date: 2-4 p.m. ET on December 8, 2020
Chairs: Jill Weimer, Sanford Research
Susan Sanchez, University of Georgia
 
2:00-2:05 p.m. Opening Remarks
Sige Zou, Program Official, ORIP, NIH
Franziska Grieder, Director, ORIP, NIH
Stephanie Murphy, Division Director, ORIP, NIH
 
2:05-3:30 p.m. Presentations:
Jill Weimer, Sanford Research
Introduction to the Validation of Large Animal Models in Research

Duncan Lascelles, North Carolina State University
Companion Animal Models of Chronic Pain

Randall Prather, University of Missouri
Swine as models of human disease and a source of organs for xenotransplantation

Peter Nghiem, Texas A&M University
Therapeutic Development in the Canine Models for Duchenne Muscular Dystrophy

Jessica Sieren, University of Iowa
The Mutualistic Relationship between Medical Imaging and Large Animal Models

Franklin West, University of Georgia
The Pig Stroke Model: Evaluating neuroprotective and regenerative therapies

Susan Sanchez, University of Georgia
Validation of Large Animal Models in Research, a Summary
 
3:30-4:00 p.m. Group Discussion
 
Session V. Validation of Non-Mouse Rodent Models for Preclinical Research
Time/Date: 2-4 p.m. ET on December 10, 2020
Chairs: Mary Dickinson, Baylor College of Medicine
Kent Lloyd, University of California Davis
 
2:00-2:05 p.m. Opening Remarks
Sige Zou, Program Official, ORIP, NIH
Franziska Grieder, Director, ORIP, NIH
Stephanie Murphy, Division Director, ORIP, NIH
 
2:05-3:30 p.m. Presentations:
Renzhi Han, The Ohio State University
A rabbit model of Duchenne muscular dystrophy for preclinical therapeutic testing

Rochelle Buffenstein, Calico Life Sciences
Breaking the mol(e)d; ther naked mole-rat a. long-lived animal model of exceptional biogerontological interest

Robert Kaminski, Walter Reed Army Institute of Research
Use of guinea pig models to assess the efficacy of enteric countermeasures

John Engelhardt, University of Iowa
Genetic Modeling in the Ferret to Study Disease Pathophysiology, Stem Cell Biology, and Genetic Therapies

Rebecca Shansky, Northeastern University
The Promise and Pitfalls of Rodent Models of Psychiatric Disease

Johan Neyts, Katholieke Universiteit Leuven-Belgium
A SARS-CoV2 hamster infection model to study the effect of vaccine candidates and antivirals
 
3:30-4:00 p.m. Group Discussion
 
Session VI. Validation of Nonhuman Primate Models for Preclinical Research
Time/Date: 2-4 p.m. ET on December 15, 2020
Chairs: John Morrison, University of California Davis
David O’Connor, University of Wisconsin-Madison
 
2:00-2:05 p.m. Opening Remarks
Sige Zou, Program Official, ORIP, NIH
Franziska Grieder, Director, ORIP, NIH
Stephanie Murphy, Division Director, ORIP, NIH
 
2:05-3:30 p.m. Presentations:

Jeff Rogers, Baylor College of Medicine
Naturally occurring primate models of human genetic diseases: An under-exploited resource

Amy Hartman, University of Pittsburg
Advances in physiological monitoring of emerging viral diseases in non-human primates

Erika Sasaki, Keio University
What do we need for the validation of disease model marmosets?

Diogo Magnani, University of Massachusetts
Development of Species-Specific Therapies and Reagents at the Nonhuman Primate Reagent Resource (NHPRR)

Jeff Kordower, Rush University
Nonhuman primate models of Neurodegenerative diseases: Parkinson’s disease, Multiple System Atrophy, and Alzheimer’s disease

Deborah L Fuller, University of Washington
Challenges and advances in nonhuman primate models of respiratory infections
 
3:30-4:00 p.m. Group Discussion
 
Session VII. Validation of Non-Zebrafish Aquatic Models for Preclinical Research (to be updated)
Time/Date: 2-4 p.m. ET on Dec. 17, 2020
Chairs: (TBA)
Speakers: John Postlethwait, University of Oregon
Crystal Rogers University of California, Davis
 
Session VIII. Technologies, Phenotyping, and Data Science for Animal Models (to be updated)
Time/Date: 2-4 p.m. ET on January 5, 2021
Chairs: Keith Cheng, Penn State College of Medicine
Stephen Ekker, Mayo Clinic

Speakers: Daniel Colon-Ramos, Yale University
Keith Cheng, Penn State College of Medicine
Scott Fraser, University of South California
Bo Zhang, Peking University
Lisa Schimmenti, Mayo Clinic
Vasant Honavar, Penn State University
Stephen Ekker, Mayo Clinic
 
Session IX. Vertical Integration Approach for Preclinical Research (to be updated)
Time/Date: 2-4 p.m. ET on January 12, 2021
Chairs: Hugo Bellen, Baylor College of Medicine
Calum A. MacRae, Brigham and Women's Hospital

Speakers: Hugo Bellen, Baylor College of Medicine
Peter Robinson, The Jackson Laboratory
John Hogenesch, Cincinnati Children’s Hospital Medical Center
Rada Savic, University of California San Francisco
 
Summary Session. Report and Discussion of Sessions I to IX (to be updated)
Time/Date: 1-4 p.m. ET on Jan. 19, 2021
Chairs: Hugo Bellen, Baylor College of Medicine
Keith Cheng, Penn State College of Medicine

Speakers: Chairs of Sessions I to IX
 
Organization Committee
Subject Matter Experts
Hugo Bellen, Chair
Keith Cheng, Co-Chair
Alan Attie
Stefania Forner
Kent Lloyd
Cathleen Lutz
John Morrison
Stacey Rizzo
William Talbot
Paul Territo
Douglas Wallace
Jill Weimer
Baylor College of Medicine
Penn State College of Medicine
University of Wisconsin -Madison
University of California, Irvine
University of California, Davis
Jackson Laboratory
University of California, Davis
University of Pittsburgh
Stanford University
Indiana University
Children’s Hospital of Philadelphia
Sanford Research
NIH Program Staff
Sige Zou, Coordinator
Kristine Abraham
Shreaya Chakroborty
Marc Charette
Miguel Contreras
Bruce Fuchs
Amelie Gubitz
Lisa Schwartz Longacre
D.P. Mohapatra
Lorenzo M. Refolo
Rebecca Roof
Xiaoli Zhao
ORIP/DPCPSI/OD/NIH
NIDDK/NIH
NIA/NIH
NHLBI/NIH
ORIP/DPCPSI/OD/NIH
ORIP/DPCPSI/OD/NIH
NINDS/NIH
NHLBI/NIH
NINDS/NIH
NIA/NIH
NINDS/NIH
NIGMS/NIH
NIH Supporting Staff
Lola Ajayi
Desiree von Kollmar
Susan Chandran
ORIP/DPCPSI/OD/NIH
ORIP/DPCPSI/OD/NIH
ORIP/DPCPSI/OD/NIH